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PUBLICATIONS & PATENTS

Publications:


SA Bogen, JM Smith, JL DuPré. 2010. Battling infringement: The unique challenges for small companies and universities. Nature Bioentrepreneur, Manuscript accepted, in press.

R Zeheb & SA Bogen.  2010.  The Evolution of the Artisan® Special Stains Instrument.  Connections (Dako Corp.), 14:203-209.

SA Bogen, K Vani, & SR Sompuram. 2009. Molecular Mechanisms of Antigen Retrieval: Antigen Retrieval Reverses Steric Interference Caused By Formalin-Induced Crosslinks.  Biotechnic & Histochem. 84(5):207-215.

SA Bogen, K Vani, B McGraw, V Federico, Iqbal Habib, R Zeheb, E Luther, C Tristram & SR Sompuram. Experimental Validation Of Peptide Immunohistochemistry Controls. 2009.  Appl. Immunohistochem & Mol Morphol.  17(3):239-246.

Vani, K, SR Sompuram, P Fitzgibbons, & SA Bogen. 2008. National HER2 proficiency test results using standardized quantitative controls. Characterization of Laboratory Failures causes. Arch Pathol Lab Med. 132 (2):211-216.

Sompuram, S, G Bastas, K Vani, & SA Bogen. 2008.  Accurate identification of paraprotein antigen targets by epitope reconstruction. Blood. 111 (1):302-308.

Bastas, B, SR Sompuram, B Pierce, K Vani, & SA Bogen.  2008.  Bioinformatic Requirements for Protein Database Searching Using Predicted Epitopes From Disease-Associated Antibodies. Mol & Cell Proteomics. 7 (2):247-256.

Vani, K, SA Bogen, & S Sompuram. 2006. A high throughput combinatorial library technique for identifying formalin-sensitive epitopes. J Immunol Methods 317(1-2):80-89.

Sompuran SR, K Vani, & SA Bogen. 2006. A Molecular Model of Antigen Retrieval Using a Peptide Array. Am. J. Clin. Pathol. 125: 91-98

Sompuram SR, K Vani, LJ Hafer, & SA Bogen. 2006. Antibodies Immunoreactive With Formalin-Fixed Tissue Antigens Recognize Linear Protein Epitopes. Am. J. Clin. Pathol. 125: 82-90.

Bogen, SA & SR Sompuram. 2004. Recent Trends and Advances in Immunodiagnostics of Solid Tumors. BioDrugs 18(6): 387-398.

Sompuram, S, K Vani, L Wei, H Ramanathan, Sarah Olken, & SA Bogen. 2004. A Water-Stable Protected Isocyanate Glass Array Substrate. Anal. Biochem. 326(1): 55-68.

Sompuram, S, K Vani, E Messana, & SA Bogen. 2004. A Molecular Mechanism of Formalin Fixation and Antigen Retrieval. Am. J. Clin. Pathol. 121(2): 190-199.

Sompuram, S, DM McMahon, K Vani, H Ramanathan, & SA Bogen. 2003. A Novel Microscope Slide Adhesive For Poorly Adherent Tissue Sections. 2003. J. Histotechnol. 26(2):117-123.

Sompuram, S, V Kodela, K Zhang, H Ramanathan, G Radcliffe, P Falb, & SA Bogen. 2002. A novel quality control slide for quantitative immunohistochemistry testing. J. Histochem. Cytochem. 50:1425-34.

Sompuram, S, V Kodela, H Ramanathan, C Wescott, G Radcliffe, & SA Bogen. 2002. Synthetic peptides identified from phage-displayed combinatorial libraries as immunodiagnostic assay surrogate quality control targets. Clinical Chemistry 48(3):410-420.


Medical Discovery Partners LLC Scientists are listed on the following patents:


U.S. Patent 7,718,435  Steven A Bogen & Herbert H.Loeffler.  Automated slide stainer with slide housing.  Issued May 18, 2010.

U.S. Patent 7,553,672  Steven A Bogen, Herbert H.Loeffler, John A Purbrick.  Random access slide stainer with independent slide heating regulation.  Issued June 30, 2009.

U.S. Patent 7,318,913 Herbert Loeffler & Steven A. Bogen.  Fluid exchange in a chamber on a microscope slide.  Issued January 15, 2008.

U.S. Patent 7,217,392.  Steven A Bogen, Herbert H Loeffler, & John A. Purbrick.  Random access slide stainer with independent slide heating regulation. Issued May 15, 2007.

U.S. Patent #7,011,940B1 Seshi R. Sompuram, Halasya Ramanathan, and Steven A. Bogen. Quality control for cytochemical assays. Issued March 14, 2006.

U.S. Patent # 6,855,490 Seshi R. Sompuram & Halasya Ramanathan. Method for attaching biological molecules to a glass surface. Issued February 15, 2005.

U.S. Patent # 6,783,733 Steven A. Bogen, Herbert H. Loeffler, & John A. Purbrick. Random access slide stainer with independent slide heating regulation. Issued August 31, 2004.

U.S. Patent # 6,673,620 Herbert H. Loeffler & Steven A. Bogen. Fluid exchange in a chamber on a microscope slide. Issued January 6, 2004.

EP 1058826 B1 Steven A. Bogen & Herbert H. Loeffler. Random access slide stainer with liquid waste segregation. Issued January 2, 2004.

U.S. Patent # 6,541,261, Steven A. Bogen, Herbert H. Loeffler, & John A. Purbrick. Method using a slide stainer with independent slide heating regulation. Issued April 1, 2003.

U.S. Patent # 6,281,004 Steven A Bogen & Gail Radcliffe. Quality control for cytochemical assays. Issued August 28, 2001.

U.S. Patent # 6,183,693 Steven A Bogen & Herbert H Loeffler. Random access slide stainer with independent slide heating regulation. Issued February 6, 2001.

U.S. Patent # 6,180,061 Steven A Bogen & Herbert H Loeffler. Moving platform slide stainer with heating elements. Issued January 30, 2001.

U.S. Patent # 6,096,271 Steven A Bogen & Herbert H Loeffler. Random access slide stainer with liquid waste segregation. Issued August 1, 2000.

U.S. Patent # 5,947,167 Steven A Bogen & Herbert H Loeffler. Dispensing assembly with interchangeable cartridge pumps. Issued Sept. 7, 1999.

U.S. Patent # 5,645,114 Steven A. Bogen & Herbert H. Loeffler. Dispensing assembly with interchangeable cartridge pumps. Issued July 8, 1997.

U.S. Patent # 5,316,452 Steven A. Bogen & Herbert H. Loeffler. Dispensing assembly with interchangeable cartridge pumps. Issued May 31, 1994.

U.S. Patent # 5,073,504 Steven A. Bogen. Apparatus and method for immunohistochemical staining. Issued Dec. 17, 1991.

U.S. Patent # 4,847,208 Steven A. Bogen. Apparatus and method for immunohistochemical staining. Issued July 11,1989.